Table 2.
Comparison of control cohort characteristics.
| Variable | Manchester AD controls | Newcastle AD controls | Auckland AD controls | PDD controls | HD controls |
|---|---|---|---|---|---|
| Number | 9 | 9 | 9 | 9 | 9 |
| Age | 89 (82–95) | 85 (76–94) | 73 (61–8)** | 87 (79–95) | 66 (49–81)** |
| Male sex, n (%) | 6 (66.6) | 6 (66.6) | 5 (55.4) | 5 (44.4) | 6 (66.6) |
| Tau Braak stage | I-II | I-II | 0**** | II | NA |
| PMD (hours) | 75 (49–130) | 25 (9–40) | 12 (5.5–15.0)** | 25 (15–48) | 12 (6.5–15)** |
| Whole-brain weight (g)† | 1160 (1020–1494) | 1235 (1064–1406) | 1260 (1094–1461) | 1126 (946–1338) | 1315 (1210–1495) |
Comparison of control group characteristics between each brain bank cohort. Age, male percentage, tau Braak stage, PMD, and whole brain weight are medians (range); p-values for significance of between-group differences were calculated by the Kruskal-Wallis test followed by Dunn's post-hoc multiple comparisons test against the PDD control group.
**
p < 0.01;
****
p < 0.0001.
†
Indicates that brain weights were not available for two samples.