Figure 8.

Neutrophil recruitment was reduced, and M2 macrophage was higher in DcR3-tg mice stimulated with MSU. MSU (3 mg/mouse) or PBS only was injected into the air pouch of DcR3-tg or WT mice. After 6 h, the lavage fluid and skin area of air pouch were collected. The skin samples were stained with H&E (A), CD206 (C), or Arg1 (D). The H&E data shown were representative for counter staining. The cells in the lavage fluid were stained with anti-Ly6G (as neutrophil marker) and F4/80 (as macrophage marker) (B). The data shown were mean ± SD of three independent experiments. The statistical significance was determined by the student t-test. *p < 0.05 was obtained by comparing DcR3-tg mice to WT mice.