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. 2021 Mar 16;11:6069. doi: 10.1038/s41598-021-85688-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Scatter plot of the distribution of plasma TrxR activity levels between liver cancer patients before clinical interventions and MLC patients after chemotherapy. (B-E) Scatter plot of the distribution of plasma TrxR (B), serum AFP (C), CEA (D), and CA19-9 (E) among MLC patients with different clinical outcome after chemotherapy (CUP vs. CRP). CUP: clinical unresponsive patient; CRP: clinical responsive patients. P values were determined by the Mann–Whitney U test. N.S: no statistical significance. (F-G) ROC curve analyses of TrxR, AFP, CEA, CA19-9 (F), and the combinations (G) for the differentiation of MLCs with different clinical outcome after chemotherapy (CUP vs. CRP).