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. 2021 Mar 16;11:5962. doi: 10.1038/s41598-021-85270-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Multimodal imaging of unrepaired vs. repaired tears of the retinal pigment epithelium (RPE). (A) and (B) composites depict the imaging features of a case of large RPE tear without signs of tissue repair. Over the follow-up the hypo-autofluorescence due to the absence of the RPE gradually enlarges as documented by blue-light autofluorescence (BAF), while the retina rests on an area of exposed Bruch’s membrane on optical coherence tomography (OCT; red asterisks). On the other hand, (C) and (D) composites show a case characterized by RPE healing. At follow-up, shrinkage of the RPE defect can be noticed using BAF, and the growth of the RPE layer with an underlying proliferative tissue is visible on OCT (green arrowheads).