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. 2021 Mar 16;11:5962. doi: 10.1038/s41598-021-85270-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Formation and remodeling of the repair tissue on optical coherence tomography (OCT) over 18 months of follow-up. (A) shows a large retinal pigment epithelial (RPE) tear involving the fovea (grade 4) with several folds of the retracted RPE and direct exposure of the Bruch’s membrane; an initial proliferative tissue can be appreciated (red asterisks). After 6 months (B), some sort of subretinal hyperreflective tissue (SHT) almost completely covers the bed of exposed Bruch’s membrane. Over the follow-up, the relative reflectivity RR) of the repair tissue gradually increases (C) and in occasion of the last visit a distinct RPE layer covering the SHT can be noticed (D, green arrowheads).