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. 2021 Mar 16;11:6037. doi: 10.1038/s41598-021-84050-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of differentially expressed genes for HUVEC between the uninfected, 1 hpi, and 16 hpi after logFC shrinkage. (A) Venn diagram visualizing the differentially expressed genes in the two comparisons with overlap showing the commonly regulated genes. (B) Heat map displaying the overall expression profile of all 295 differentially expressed genes grouped into 2 clusters indicating either up- or downregulation at specific time points during infection. Gene expression values have been log2 transformed and hierarchically clustered according to Euclidean distances with complete linkage. (C) Functional enrichment analysis of HUVEC genes that have been mapped to the Reactome Pathway database.