Table 1.
SVID and CADASIL-like exome sequencing cohort.
| Country of origin | N | Disease | AAO (SD) | M:F | N cases with family history (%) | Hypertension (%) | Diabetes (%) | N cases with migraine (%) | N cases with heart comorbidities (MI, AF) (%) | N cases with hypercholesterolemia (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| US | 96 | SVID | 51.5 (8.1) | 0.82 | 43 (44.7) | 58 (60.4) | 29 (30.2) | NA | 11 (11.4) | 2 (2) |
| Portugal | 34 | CADASIL-like | 44.5 (12.3) | 0.36 | 9 (26.5) | NA | NA | 9 (26.5) | 1 (3) | NA |
| Finland | 33 | CADASIL-like | 60.5 (12.2) | 0.74 | 16 (48.5) | 22 (66.6) | 4 (12.1) | 9 (27.3) | 10 (30.3) | 11 (33.3) |
| Serbia | 15 | CADASIL-like | NA | 0.63 | 7 (46.6) | NA | NA | NA | NA | NA |
| Turkey | 2 | CADASIL-like | NA | 0.5 | 1 (50) | NA | NA | NA | NA | NA |
| Total or average | 180 (96 + 84) | 52 (10.9) | 0.71 | 76 (42.2) | 80 (44.4) | 33 (18.3) | 18 (10) | 22 (12.2) | 13 (7.2) |
SVID small vessel ischemic disease, AAO age at onset, SD standard deviation, M male, F female, MI myocardial infarction, AF atrial fibrillation.