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. 2021 Mar 16;13:9. doi: 10.1038/s41368-021-00113-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — SDF-1-loaded PLGA nanoparticles for tongue squamous cell carcinoma photothermal therapy. a The schematic shows the construction of multifunctional PLGA NPs as a visualizable targeted chemotherapy agent for the codelivery of ICG and DOX, lymph node targeting, and chemical-photothermal combination therapy. b ICG (green fluorescence) and DOX (red fluorescence) were engulfed by SCC-15 cells, as shown by CLSM (×800 magnification). DAPI stains the nucleus blue. a: Experimental group: SDF-1/ICG/PFH/DOX/PLGA NPs; b: control group I: ICG/PFH/DOX/PLGA NPs; c: control group II: cells were blocked with excess SDF-1 before the addition of SDF-1/ICG/PFH/DOX/PLGA NPs. c Apoptosis rates of SCC-15 cells with and without laser irradiation measured by flow cytometry. d In vivo therapeutic effect, displayed as tumour weight.⁶⁸ Copyright 2019, Elsevier