Supplementary Table 1.

PK properties of compound 10.

Compound 10 mouse PK
IV (1 mg/kg)	T1/2	1.23 h
	AUCinf	1.86 μM∗h
	Vss	1.71 L/kg
	CL	22.7 mL/kg∗min
PO (10 mg/kg)	Tmax	0.67 h
	Cmax	1.62 μM
	AUCinf	4.66 μM∗h
	F%	25.5%

PK: pharmacokinetics. IV: intravenous. PO: per os. CL: clearance. Vss: steady state volume of distribution. F%: oral bioavailability.