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Schema illustrating how GluTR N-degrons can be masked and unmasked by the GluTR-binding protein (GBP). In the absence of heme, GBP binds to the N-degron of GluTR protein and prevents its degradation by the Clp system (masked N-degron). When heme levels increase, the release of GBP from GluTR1 enables the binding of ClpS1 and ClpF adaptors to the latter and its concomitant proteolytic degradation (unmasked N-degron) (106).
