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. 2021 Feb 27;21:54–66. doi: 10.1016/j.omtm.2021.02.021

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Schematic proposal for a BRD4/CEBPD partnership associated with chromatin

TNF-α as extracellular signal stimulates upregulation of epigenetic reader protein BRD4, which, while reading H3K27ac, functions in the same complex with transcription factor CEBPD and unknown co-factors (light green background). BRD4 and CEBPD stock up at Cebpd promoter and enhancer to prompt the transcription of Cebpd. Increased CEBPD elevates the expression of its target genes such as Pdgfra and propels the inflammatory SMC state transition.