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. 2021 Mar 10;65:103271. doi: 10.1016/j.ebiom.2021.103271

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 3 — Establishment and evaluation of m6Ascore model in PDAC patients. (a) Kaplan-Meier survival analysis based on m6Ascore in ICGC-PDAC cohort (P = 0.0023, log-rank test); (b) Principal component analysis (PCA) of TCGA-PDAC patients based on the expression of the m6Ascore model; (c) Heatmap showed the expression profiles of nine m6A regulators that enrolled in the m6Ascore model in TCGA-PDAC patients. m6Ascore risk was listed as column annotations; Gradient m6Ascore was listed from left to right; (d) Expression of several key regulators of tumor metastasis were upregulated in m6Ascore-high patients than in m6Ascore-low patients; (e) COX regression and forest plot were applied to examine the hazard ratio (HR) and 95% confidence interval of each m6A regulators and the m6Ascore model.