Figure 4.

Adaptation in GVS modulated afferent response

(A) The full adaptation is composed of a change in firing rate due to axonal response (purple) and hair cell adaptation, (blue) which responds to changes in internal current.

(B) We can tune adaptation gains and time constants to get adaptation that resembles experimental in vitro results from Manca et al. (2019) to −10 μΑ of cathodic (blue) and anodic (red).

(C) We find a significant baseline shift with anodic and cathodic current in the experimental results in the in vitro study (t(9) = 2.37, p = 0.042).

(D) Without considering baseline shift and the firing range limits (fr_axon = 0, maximum firing rate 55 sps) the spike rate changes to current steps are predicted to be the same after baselines of anodic (red), cathodic (blue), and control or zero baseline (black) using fr(t) as they overlap on the plot (left). When fr_axon= fr_o, fr(t) resembles experimental results in plot (E).

(E) We use fr_adapt(t) to modulate μ₀(t) in our full model. Traces are in the same colors. A non-parametric cluster statistic is used to compare anodic with cathodic step response (green) within conditions. The in vitro experimental data (above) and simulated data (below) was tested for significant differences between conditions with anodic-control (red), cathodic-control (blue), and anodic-cathodic non-parametric cluster statistic (green) shown on each image. All statistical data are presented as mean ± std.