Figure 4. Effect of Vitamin D₃ on the Primary End Point in Prespecified Subgroups.

^aCox regression models controlled for age, sex, and randomization group; interactions tested using multiplicative interaction terms.

^bIncludes Hispanic, Asian/Pacific Islander, Native American/Alaska Native, and other, multiple, or unspecified race/ethnicity.

^cCHA₂DS₂-VASc score estimates stroke risk in patients with atrial fibrillation (see Table 1 footnote "d" for details). Risk factors were self-reported at baseline. Scores ranged from 0 to 8 in this study.

^dRestricted to ≤800 IU/d from all sources combined.