Figure 12.

Trehalose‐delivery technology via responsive nanoencapsulation materials. A) The schematic illustration of encapsulating trehalose in pH‐responsive nanoparticles. B) Comparison of cell viabilities using different CPA treatments. A,B) Reproduced with permission.^{[ 153 ]} Copyright 2015, American Chemical Society. C) Schematic illustration of trehalose release. D) Cold‐responsive nanoparticles enhanced the cryopreservation efficiency. C,D) Reproduced with permission.^{[ 161 ]} Copyright 2019, American Chemical Society. E) Cold‐responsive nanoparticles and hydrogel synergistically reduced ice injury and facilitated the cryopreservation of β cells, and the recovered cells were transplanted for treatment. Reproduced with permission.^{[ 162 ]} Copyright 2019, Wiley‐VCH.