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. 2021 Mar 9;22(5):2773. doi: 10.3390/ijms22052773

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CRH increased the expression of CRH-R1 on tryptase+ hM-MCs and upregulated tryptase immunoreactivity within the hM-MCs. Percentage of (a) tryptase+ and (b) c-Kit+ MCs with CRH-R1 in the lamina propria of organ-cultured human NPs, analyzed by double immunofluorescence of tryptase or c-Kit/CRH-R1. n = 7 in (a) and 4 in (b). (c) Tryptase immunoreactivity within the hM-MCs in NPs treated with vehicle or CRH. CRH treatment significantly increased tryptase immunoreactivity within hM-MCs. n = 5; scale bar = 10 µm. Error bars indicate SEM. * p < 0.05, N.S. = not significant. MC, mast cell; hM-MCs, human nasal mucosa MCs; NPs, nasal polyps; CRH, corticotropin-releasing hormone; CRH-R1, CRH receptor type 1.