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. 2021 Mar 9;22(5):2760. doi: 10.3390/ijms22052760

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of apelin on caspase 3 and 7 activity and histone-associated DNA fragment level in BeWo cells. The cells were incubated with 2 and 20 ng/mL of apelin alone or in combination with 0.1 µL/mL staurosporine for 24, 48 and 72 h, after which caspase 3 and 7 activity (A,B) was analysed using the Caspase-Glo 3/7 assay or the level of histone-associated DNA fragments (C,D) by the Cell Death Detection ELISA kit. Experiments were independently performed and repeated three times (n = 3). The data are arranged as means ± SEM. Different letters indicate significant differences (p < 0.05) among groups; Control (C), Staurosporine (S), Relative Luminescence Unit (RLU), Relative Absorbance Unit (RAU).

Effect of apelin on caspase 3 and 7 activity and histone-associated DNA fragment level in BeWo cells. The cells were incubated with 2 and 20 ng/mL of apelin alone or in combination with 0.1 µL/mL staurosporine for 24, 48 and 72 h, after which caspase 3 and 7 activity (A,B) was analysed using the Caspase-Glo 3/7 assay or the level of histone-associated DNA fragments (C,D) by the Cell Death Detection ELISA kit. Experiments were independently performed and repeated three times (n = 3). The data are arranged as means ± SEM. Different letters indicate significant differences (p < 0.05) among groups; Control (C), Staurosporine (S), Relative Luminescence Unit (RLU), Relative Absorbance Unit (RAU).