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. 2021 Mar 9;22(5):2760. doi: 10.3390/ijms22052760

Figure 5.

Figure 5

Effect of apelin on DNA fragmentation in villous explants from human placenta. The explants were incubated with apelin at 2 and 20 ng/mL for 24, 48 and 72 h, and the level of histone-associated DNA fragment was measured using the Cell Death Detection ELISA kit. Experiments were performed on five independent cultures of human placenta explants (n = 5). The level of DNA fragmentation was calculated to 100 µg protein of villous explants and then as percentage compared to the 24-h control sample (100%). The data are arranged as means ± SEM. Different letters indicate significant differences (p < 0.05) among groups; Control (C).