Table 2.

Examples of several combinational Approaches of TA and other anticancer agents.

Drug	Dosage Form	Cell Line	Most Important Key Finding	References
Oxaliplatin	Polymeric nanoparticle	CT26	Synergistic inhibitory effect of oxaliplatin and TA	[49]
Paclitaxel	Nanoparticle	MDA-MB-231	Reduced IC50 & increased cellular uptake of the drug compared to free drug	[36]
Gemcitabine, 5-Flurouracil &irinotecan	Nanocomplex	HPAF-II and PANC-1	Lower IC50 value& increased cellular uptake for the drugs	[40]
Gemcitabine, carboplatin &irinotecan	Nanocomplex	A549 and H1299	Enhanced decrease in IC50 from drug-loaded nanocomplex fabricated from TA and mice lung fluid	[50]
Doxorubicin hydrochloride	Polymeric nanoparticle	HeLa	Similar inhibitory action of the nanoparticles compared to the free drug at the same concentration of 5 mg/mL	[51]
Nobelitin	Coated nanoparticle	H1299	Improved anticancer effect as well as good cytocompatibility at nobelitin concentration of 80 µg/ mL	[52]
Paclitaxel	Nanocomplex	A549	Lower IC50 values compared to both the pure drug and uncoated nanoparticles	[53]