Table 3.
Genes with log2FC > 4.0 in specific MPS type relative to control cells (HDFa). Up-arrowed and down-arrowed symbols indicate up- and downregulation, respectively, while minus symbols indicate no significant changes.
| GO Term/Gene | Extremely Changed Transcripts (log2FC > 4) in Particular MPS Type vs. HDFa Line | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cellular Component Organization | I | II | IIIA | IIIB | IIIC | IIID | IVA | IVB | VI | VII | IX |
| TNFRSF11B | - | - | - | - | - | - | - | - | - | ↓ | - |
| CAV1 | ↓ | - | - | - | - | - | - | ↓ | - | - | - |
| WISP2 | - | - | ↓ | ↓ | - | - | - | - | - | - | - |
| APOE | - | - | ↓ | - | - | - | - | - | - | - | - |
| SNX3 | - | - | - | - | ↓ | - | - | - | - | - | - |
| SPON2 | - | - | ↓ | - | - | - | - | - | - | - | - |
| WISP2 | - | - | - | ↓ | - | - | - | - | - | - | - |
| MMP12 | - | - | ↓ | ↓ | ↓ | - | - | - | - | - | ↓ |
| MMP3 | - | - | - | - | - | - | - | - | - | - | ↓ |
| IGFBP5 | - | - | - | - | - | ↑ | - | - | - | - | ↑ |
| COMP | - | - | - | - | - | ↑ | - | - | - | - | - |
| COL8A2 | - | - | - | - | ↑ | ↑ | - | - | - | - | - |
| CD9 | - | - | - | ↑ | - | - | - | ↑ | - | - | - |
| CAPG | - | - | ↑ | - | ↑ | - | ↑ | ↑ | - | ↑ | ↑ |
| POSTN | ↑ | - | ↑ | ↑ | ↑ | ↑ | - | ↑ | ↑ | ↑ | ↑ |
| POSTN | ↑ | - | ↑ | ↑ | ↑ | ↑ | - | ↑ | ↑ | - | ↑ |
| POSTN | ↑ | - | ↑ | ↑ | - | ↑ | - | ↑ | ↑ | ↑ | ↑ |
| KRT19 | - | - | - | - | - | - | - | ↑ | - | - | - |
| OXTR | - | - | - | ↑ | ↑ | ↑ | - | ↑ | - | - | ↑ |
| MFAP5 | - | ↑ | ↑ | ↑ | ↑ | - | - | ↑ | ↑ | ↑ | ↑ |
| Cellular anatomical entity | I | II | IIIA | IIIB | IIIC | IIID | IVA | IVB | VI | VII | IX |
| EMP1 | - | - | - | - | ↓ | - | ↓ | - | - | - | - |
| RARRES2 | - | - | ↓ | ↓ | - | - | - | - | - | - | - |
| PTGS1 | - | - | - | - | - | - | - | - | - | ↓ | - |
| APOE | - | - | ↓ | - | - | - | - | - | - | - | - |
| THBS1 | - | ↓ | - | - | - | - | - | ↓ | - | - | - |
| GNS | - | - | - | - | - | ↓ | - | - | - | - | - |
| RPL23 | - | - | - | - | ↓ | ↓ | ↓ | - | - | - | - |
| PTGS1 | ↓ | - | - | - | - | - | - | - | - | - | - |
| PTGS1 | - | - | - | - | - | - | - | - | - | ↓ | - |
| PTGDS | - | - | ↓ | ↓ | ↓ | - | - | ↓ | - | ↓ | ↓ |
| EMP1 | - | - | - | - | ↓ | - | ↓ | - | - | - | - |
| CAV1 | ↓ | - | - | - | - | - | - | ↓ | - | - | - |
| RPL10 | - | - | - | - | - | ↓ | - | - | - | - | - |
| POSTN | ↑ | - | ↑ | ↑ | ↑ | ↑ | - | ↑ | ↑ | ↑ | ↑ |
| POSTN | ↑ | - | ↑ | ↑ | ↑ | ↑ | - | ↑ | ↑ | - | ↑ |
| POSTN | ↑ | - | ↑ | ↑ | - | ↑ | - | ↑ | ↑ | - | - |
| CD9 | - | - | - | ↑ | - | - | - | ↑ | - | - | - |
| MFGE8 | - | - | ↑ | - | - | - | - | - | - | - | - |