Figure 2. Absolute Lymphocyte Count and Lymphocyte Subset Timelines.
A, Absolute lymphocyte count values from 4 years prior to ocrelizumab initiation until shortly after progressive multifocal leukoencephalopathy (PML) onset. Prior to the development of PML, the patient exhibited intermittent mild (grade 1) lymphopenia, with absolute lymphocyte count values ranging from 800 to 1200 cells/μL (to convert to ×109/L, multiply by 0.001). B, Lymphocyte subsets at several times points after ocrelizumab initiation. No prior lymphocyte subset panel was obtained. CD19 cell counts (not shown) remained near 0 at all time points. Horizontal dashed lines correspond with lower limit of normal of each y-axis value. Vertical dashed line corresponds with ocrelizumab initiation, and vertical dashed arrow corresponds with PML symptom onset.