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. 2021 Mar 16;78(6):1–6. doi: 10.1001/jamaneurol.2021.0627

Figure 3. Histopathology (Paraffin Sections) .

Figure 3.

A, Occipital white matter: JC virus inclusions (arrowheads) in the infected oligodendrocytes (immunohistochemistry with immunomarker for SV40; hematoxylin counterstain; bar, 50 μm). B, Discrete demyelination patches (arrowheads) in occipital lobe white matter (low-power magnification; myelin stain with Luxol fast blue and periodic acid–Schiff counterstain; bar, 800 μm). C and D, Cerebral white matter showing patches of demyelination where myelin is replaced by mild inflammatory reaction (arrowheads; medium to high power; hematoxylin-eosin stain; bar, 400 μm).