. 2021 Mar 9;18(5):2774. doi: 10.3390/ijerph18052774

Table 4.

Nuuk and Ilulissat women: Age stratified time trend of lipPOPs, metals and PFASs level.

Chemical	Nuuk Women (1999–2015), Median Age 30 Years (Min-Max: 15–66)
	≤ 30 Years								>30 Years
	Raw				Adjusted ^a				Raw				Adjusted ^a
	n	β	95% CI	p	n	β	95% CI	p	n	β	95% CI	p	n	β	95% CI	p
LipPOPs (µg/kg lipid)
ln PCB153	387	−0.08	−0.09; −0.06	<0.0001	387	−0.08	−0.09; −0.06	<0.0001	333	−0.17	−0.18; −0.15	<0.0001	333	−0.11	−0.13; −0.09	<0.0001
ln p,p’-DDE	386	−0.08	−0.09; −0.06	<0.0001	386	−0.08	−0.09; −0.06	<0.0001	333	−0.16	−0.18; −0.15	<0.0001	333	−0.10	−0.12; −0.08	<0.0001
ln Oxychlordane	386	−0.07	−0.08; −0.05	<0.0001	386	−0.06	−0.08; −0.05	<0.0001	333	−0.20	−0.22; −0.17	<0.0001	333	−0.13	−0.16; −0.10	<0.0001
Metals (µg/L)
ln Hg	377	−0.004	−0.02; 0.01	0.614	377	−0.01	−0.02; 0.01	0.464	201	−0.02	−0.04; 0.003	0.084#	201	−0.04	−0.06; −0.01	0.002
ln Pb	377	−0.06	−0.07; −0.05	<0.0001	377	−0.06	−0.07; −0.05	<0.0001	201	−0.08	−0.10; −0.06	<0.0001	201	−0.07	−0.09; −0.05	<0.0001
ln Se	377	−0.02	−0.03; −0.01	<0.0001	377	−0.02	−0.03; −0.01	<0.0001	201	−0.03	−0.04; −0.02	<0.0001	201	−0.03	−0.04; −0.02	<0.0001
Nuuk women (1998–2015), Median age 30 years (min-max: 17–66)
PFASs (ng/mL)
ln PFHxS	246	−0.19	−0.23; −0.15	<0.0001	246	−0.19	−0.23; −0.15	<0.0001	235	−0.13	−0.14; −0.11	<0.0001	235	−0.09	−0.15; −0.02	0.010
ln PFOS	246	−0.06	−0.10; −0.02	0.003	246	−0.06	−0.10; −0.02	0.003	235	−0.11	−0.12; −0.09	<0.0001	235	−0.06	−0.13; 0.01	0.105
ln PFOA	246	−0.05	−0.10; −0.01	0.019	246	−0.05	−0.10; −0.01	0.019	235	−0.07	−0.08; −0.06	<0.0001	235	−0.04	−0.10; 0.02	0.213
ln PFNA	246	−0.02	−0.06; 0.01	0.226	246	−0.02	−0.06; 0.01	0.226	235	−0.02	−0.03; 0.002	0.076 ^#	235	−0.01	−0.08; 0.07	0.890
ln PFDA	246	0.02	−0.03; 0.06	0.505	246	0.02	−0.03; 0.06	0.505	235	−0.01	−0.02; 0.01	0.607	235	0.03	−0.05; 0.12	0.427
ln PFUnA	246	0.04	−0.03; 0.11	0.299	246	0.04	−0.03; 0.11	0.299	235	−0.01	−0.03; 0.01	0.326	235	0.01	−0.09; 0.11	0.827
Chemical	Ilulissat women (1994–2015), Median age 26 years (min-max: 15–43)
	≤26 years								>26 years
	Raw				Adjusted ^a				Raw				Adjusted ^a
	n	β	95% CI	p	n	β	95% CI	p	n	β	95% CI	p	n	β	95% CI	p
LipPOPs (µg/kg lipid)
In PCB153	184	−0.07	−0.08; −0.05	<0.0001	184	−0.05	−0.08; −0.01	0.014	162	−0.08	−0.09; −0.06	<0.0001	162	−0.06	−0.10; −0.01	0.014
ln p,p’-DDE	177	−0.07	−0.09; −0.05	<0.0001	177	−0.06	−0.10; −0.02	0.004	152	−0.07	−0.09; −0.05	<0.0001	152	−0.05	−0.09; 0.00	0.049
ln Oxychlordane	184	−0.06	−0.08; −0.04	<0.0001	184	−0.05	−0.10; −0.01	0.031	162	−0.07	−0.09; −0.04	<0.0001	162	−0.04	−0.10; 0.03	0.294
Metals (µg/L)
ln Hg	158	−0.07	−0.09; −0.05	<0.0001	158	−0.02	−0.06; 0.02	0.319	140	−0.05	−0.07; −0.03	<0.0001	140	0.01	−0.04; 0.06	0.723
ln Pb	158	−0.10	−0.11; −0.09	<0.0001	158	−0.02	−0.04; 0.01	0.289	141	−0.10	−0.11; −0.09	<0.0001	141	−0.03	−0.07; −0.004	0.027
ln Se	156	0.04	0.03; 0.05	<0.0001	156	0.04	0.02; 0.07	<0.0001	139	0.05	0.04; 0.06	<0.0001	139	0.05	0.01; 0.08	0.005

LipPOP: legacy lipophilic POPs; PFASs: perfluoroalkylated substances; ^a Data was adjusted for pregnancy status (Nuuk pregnant women: age ≤ 30 years: n = 338 for lipPOPs and metals, n = 246 for PFASs; age > 30 years: n = 176 for lipPOPs and metals, n = 169 for PFAS data set. Ilulissat pregnant women: age ≤ 26 years: n = 64; age > 26 years: n = 46 for lipPOPs and metals). n: number of participants in the analysis. Bold indicate statistical significance (p <0.05). ^#: Borderline significant (0.05 < p < 0.10). PFASs in Ilulissat participants were not performed time trend analysis stratified by age due to small sample size (n = 79) and only had four time series. For the full name of chemicals, please refer to the abbreviation list.