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. Author manuscript; available in PMC: 2022 Jan 6.
Published in final edited form as: ACS Chem Neurosci. 2020 Dec 16;12(1):79–98. doi: 10.1021/acschemneuro.0c00561

Figure 5.

Figure 5.

(S)-EU1180–154 potentiation requires the NMDA receptor TMD. (A) Cartoon representations showing construction of chimeric subunits from GluK2/GluN1 and GluK2/GluN2B. (B–E) Whole-cell currents evoked by 10 μM NMDA and 10 μM glycine (N+g) or 10 μM kainate (K) to transfected HEK cells expressing chimeric receptors. (S)-EU1180–154 was applied as indicated by the gray bars. The effects of 3 μM (S)-EU1180–154 (mean, SEM, N) are summarized in Supplemental Table S6. The holding potential was −80 mV.