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. 2021 Mar 4;18(5):2529. doi: 10.3390/ijerph18052529

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of anti-rheumatic treatment (methotrexate (MTX) and anti-tumor necrosis factor-α (anti-TNF) in addition to MTX) on clinical and laboratory parameters of rheumatoid arthritis (RA) and periodontitis. Each line in the figures represents one patient over time in the study. (A) Clinical parameters: RA disease activity (DAS28) and periodontal inflamed surface area (PISA). (B) Laboratory parameters: erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. (C) IgG antibody levels against Porphyromonas gingivalis (anti-Pg). T0: baseline, T1: after 2 months treatment of MTX and after 3 months treatment of anti-TNF in addition to MTX, T2: after 6 months treatment of anti-TNF in addition to MTX, ns: not significant.