Table 1.
Patient characteristics at baseline (IQR: interquartile range).
| Patient Group | MTX | Anti-TNF |
|---|---|---|
| Number | 14 | 12 |
| Age in years (IQR) | 61 (49–66) | 64 (57–67) |
| Female gender (%) | 71 | 75 |
| Current smoker (%) | 21 | 17 |
| anti-CCP2 seropositive (>25 U/mL) (%) | 57 | 92 |
| IgM RF seropositive (>10 IU/mL) (%) | 71 | 83 |
| CRP (mg/L) median (IQR) | 19 (1.3–47) | 5.4 (2.9–21) |
| ESR (mm/h) median (IQR) | 37(12–77) | 22 (10–56) |
| DAS28 (IQR) | 5.8 (3.8–6.5) | 5.3(4.2–5.8) |
| Intra-oral characteristics | ||
| Number of teeth (IQR) | 26 (24–29) | 25 (23–27) |
| Pocket probing depth ≥4 mm (% of sites per patient) (IQR) | 8.0 (2.2–24) | 8.5 (5–16) |
| Bleeding on probing (% of sites per patient) (IQR) | 10 (7–23) | 15 (11–21) |
| Periodontal inflamed surface area (PISA) in cm2 (IQR) | 1.7 (1.4–4.0) | 1.9 (1.2–3.2) |
| Periodontal diagnosis (number of patients, %) | ||
| Gingivitis | 8 (57) | 8 (67) |
| Moderate periodontitis | 4 (29) | 4 (33) |
| Severe periodontitis | 2 (14) | 0 |
| Presence of other intra-oral pathologies (number of patients,%): | ||
| Furcation involvement | 3 (21) | 5 (42) |
| Peri-apical pathology | 3 (21) | 2 (17) |
| Caries | 2 (14) | 2 (17) |
| Subgingival microbial characteristics (number of patients culture positive for,%): | ||
| Porphyromonas gingivalis | 2 (14) | 0 |
| Prevotella intermedia | 8 (57) | 8 (67) |
| Tannerella forsythia | 9 (64) | 5 (42) |
| Parvimonas micra | 13 (93) | 10 (83) |
| Campylobacter rectus | 8 (57) | 4 (33) |