Table 2.
Concentrations of urinary 8-epi-PGF2α and PGE-M among all control subjects and subgroups stratified by body mass index, smoking status, alcohol intake and serological status of HBsAg, the Shanghai Cohort Study
| Subject group | 8-epi-PGF2α (pmol/mg creatinine) | PGE-M (pmol/mg creatinine) | ||
|---|---|---|---|---|
| N a | Geometric mean (95% CI)b | N a | Geometric mean (95% CI)b | |
| All control subjects | 667 | 0.78 (0.66, 0.90) | 660 | 25.8 (19.5, 34.0) |
| By body mass index (kg/m2) | ||||
| <18.5 | 67 | 0.72 (0.60–0.86) | 68 | 23.9 (17.2–3.2) |
| 18.5–<23.0 | 358 | 0.80 (0.68–0.94) | 353 | 27.7 (20.9–36.7) |
| 23.0–<27.0 | 206 | 0.76 (0.64–0.88) | 204 | 23.6 (17.6–31.5) |
| ≥27.0 | 36 | 0.68 (0.56–0.84) | 35 | 20.2 (13.8–29.5) |
| P | 0.297 | 0.0580 | ||
| By smoking status | ||||
| Never smokers | 311 | 0.68 (0.58–0.80) | 308 | 25.0 (18.8–33.2) |
| Former smokers | 44 | 0.76 (0.62–0.94) | 44 | 28.4 (19.7–40.9) |
| Current smokers | 312 | 0.88 (0.76–1.04) | 308 | 26.5 (19.9–35.3) |
| P | <0.001 | 0.393 | ||
| By alcohol consumption | ||||
| Nondrinkers | 380 | 0.76 (0.64–0.88) | 372 | 25.8 (19.4–34.3) |
| <4 Drinks/day | 230 | 0.78 (0.66–0.90) | 232 | 25.8 (19.3–34.5) |
| ≥4 Drinkers/day | 57 | 0.90 (0.74–1.08) | 56 | 25.6 (18.3–35.9) |
| P | 0.033 | 0.976 | ||
| By HBsAg status | ||||
| Negative | 592 | 0.74 (0.64–0.88) | 585 | 25.1 (19.1–33.0) |
| Positive | 75 | 0.80 (0.68–0.96) | 75 | 26.5 (19.4–36.1) |
| P | 0.244 | 0.581 |
aTwenty-four subjects were excluded due to missing 8-epi-PGF2α, and 31 subjects were excluded due to missing PGE-M (the details were described in the Methods).
bAdjusted for age, year of biospecimen collection, neighborhood of residence, body mass index (<18.5, 18–<23, 23–<27, 27+ kg/m2), cigarette smoking (never, former, current smoker), alcohol consumption (non-drinker, <4 drinks per day, ≥4 drinks per day), self-reported history of physician-diagnosed liver cirrhosis (no, yes) and serological status of HBsAg (negative, positive).