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. 2021 Feb 25;21(5):423. doi: 10.3892/etm.2021.9867

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Knockdown of SNHG1 inhibits cell proliferation and migration of hHCtASMCs. (A) The expression of SNHG1 was successfully reduced by si-SNHG1 in hHCtASMCs. (B) In hHCtASMCs, knockout of SNHG1 inhibited cell proliferation. (C and D) The migration of hHCtASMCs decreased significantly after transfection with si-SNHG1. (C) Representative images of Transwell membranes (magnification, x100) and (D) quantified numbers of migratory cells in each group. ^**P<0.01 and ^***P<0.001 vs. control. si-SNHG1, short interfering RNA targeting small nucleolar RNA host gene 1; hHCtASMCs, human carotid artery smooth muscle cells; NC, negative control; OD, optical density.