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. 2021 Feb 25;21(5):423. doi: 10.3892/etm.2021.9867

Figure 4.

Figure 4

miR-145 mediates the effects of SNHG1 on hHCtASMC proliferation and migration. (A) The expression level of miR-145 was decreased by miR-145 inhibitor and increased by si-SNHG1, and knockout of SNHG1 reversed the downregulation of miR145 expression levels by miR-145 inhibitor. (B) Effect of miR-145 inhibitor and si-SNHG1 on the proliferation of hHCtASMCs. (C and D) Effect of miR-145 inhibitor and si-SNHG1 on the migration of hHCtASMCs. (C) Representative images of Transwell membranes (magnification, x100) and (D) quantified numbers of migratory cells in each group. The proliferation and migration of hHCtASMCs were significantly increased after transfection with miR-145 inhibitor and significantly decreased after knockout of SNHG1. si-SNHG1 was able to eliminate the promotion effect of miR-145 inhibitor on the proliferation and migration of human colon cancer cells. *P<0.05 and ***P<0.001 vs. control; #P<0.05, ##P<0.01 vs. si-SNHG1. miR, microRNA; si-SNHG1, short interfering RNA targeting small nucleolar RNA host gene 1; hHCtASMCs, human carotid artery smooth muscle cells; NC, negative control; OD, optical density.