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PGRN-positive microglia in the hippocampi of brains with different diseases. Sparse PGRN-positive microglia are present in the CA1 region in normal controls (CON, A) and in FTLD-TDP type A with GRN mutations (GRN+/−, B). Frequent PGRN-positive microglia are found in the CA1 region in Alzheimer disease with hippocampal sclerosis (ADHS, C) and FTLD-TDP type A without GRN mutations (FTLD-TDP type A, D). Bar: 50 µm.
