Figure 4.
Inhibition of the AMPK pathway decreases type I collagen expression. Effects of ERK and AMPK inhibitors on emodin-induced type I collagen synthesis. Cells were pre-incubated with 10 µM MEK inhibitor U0126 (A) or the AMPK inhibitor compound c (B) for 30 min and subsequently treated with emodin for the indicated time. *P<0.05; **P<0.01. AMPK, 5' AMP-activated protein kinase.