Table 3.
GO biological functions from differentially expressed genes between biopsies A and B in the tubulointerstitium
| GO biological process | Ref. list | Hits | Fold enrichment | Biopsy A versus B | P |
|---|---|---|---|---|---|
| Regulation of type I IFN-mediated signaling pathway (IFNA1, IFNB1, STAT1, IRF7) | 42 | 4 | >100 | >A | 5.18 × 10−04 |
| Type I IFN signaling pathway (IFNA1, IFNB1, STAT1, EGR1, MX1, IRF7) | 65 | 6 | >100 | >A | 1.97 × 10−07 |
| Negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (IL7R, IFNB1, IL4R) | 36 | 3 | 92.1 | >B | 4.09 × 10−02 |
| Negative regulation of viral life cycle (PML, IFNB1, LTF, MX1) | 75 | 4 | 59.0 | >A | 5.17 × 10−03 |
| Leukocyte proliferation (IL7R, KIT, IFNA1, IFNB1) | 88 | 4 | 50.2 | >B | 9.72 ×10−03 |
| Lymphocyte differentiation (IL7R, KIT, IFNA1, IFNB1, EGR1) | 221 | 5 | 25.0 | >B | 1.13 ×10−02 |
| T cell activation (IL7R, KIT, IFNA1, IFNB1, EGR1) | 226 | 5 | 24.5 | >B | 1.27 × 10−02 |
| Regulation of vasculature development(C3, KIT, PML, STAT1, EGR1) | 248 | 5 | 22.3 | >B | 1.99 × 10−02 |
Ref. list (reference list) indicates the number of genes in a particular biological pathway. Hits indicates the number of differentially expressed genes included in the pathway. Fold enrichment represents the enrichment score that reflects the degree to which a set of differentially expressed genes is overrepresented in the biopsies A or B [18]. The P-value is the estimation of significance level of the enrichment score.