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. 2021 Mar 3;21(5):460. doi: 10.3892/etm.2021.9891

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Copyright: © Choi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Increased suppressive activity of Tregs by 4-PBA treatment in murine lupus. (A) Flow cytometric analysis of proliferation of target cells (CD4⁺CD25^- T cells) in the presence or absence of Tregs of VEH-, 4-PBA- and DEXA-treated mice groups. CD4⁺CD25⁺ regulatory T cells (3x10⁴ cells/well) from each group were co-cultured with CFSE-labeled CD4⁺CD25^- target cells of BALB/c at a ratio of 1:1 for 5 days. (B) Inhibitory index of target cell proliferation indicating the suppressive capacity of Tregs. ^*P<0.05 vs. BALB/c mice; ^#P<0.05 vs. vehicle-treated mice. Results are presented as the mean ± EM of three independent experiments per group. 4-PBA, 4-phenylbutyric acid; Tregs, regulatory T cells; DEXA, dexamethasone; VEH, vehicle.