Table 2.
Cumulative prevalence of comorbidities and ulcerative colitis disease extent
| Checking all available history up to (the last day of) each period | |||||
|---|---|---|---|---|---|
| Year-5 (-1461) |
Year-4 (-1081) |
Year-3 (-721) |
Year-2 (-366) |
Year-1 (-1) |
|
| Comorbidities, n (% of 1891) | |||||
| Anemia | 182 (9.6%) | 288 (15.2%) | 397 (21.0%) | 517 (27.3%) | 784 (41.5%) |
| Diabetes | 107 (5.7%) | 136 (7.2%) | 173 (9.1%) | 213 (11.3%) | 257 (13.6%) |
| Hypertension | 88 (4.7%) | 177 (9.4%) | 258 (13.6%) | 335 (17.7%) | 422 (22.3%) |
| Stroke | 4 (0.2%) | 12 (0.6%) | 22 (1.2%) | 36 (1.9%) | 50 (2.6%) |
| Osteoporosis | 25 (1.3%) | 57 (3.0%) | 77 (4.1%) | 102 (5.4%) | 129 (6.8%) |
| UC extent (hierarchical)a, overallb | |||||
| 5-year UC diagnosis record, N (%) | 1885 (100) | 1885 (100) | 1885 (100) | 1885 (100) | 1885 (100) |
| Extensive/pancolitis, n | 298 (16) | 450 (24) | 562 (30) | 720 (38) | 1117 (59) |
| Left-sided, n | 112 (6) | 168 (9) | 196 (10) | 215 (11) | 272 (14) |
| Proctitis/Proctosigmoiditis, n | 88 (5) | 127 (7) | 156 (8) | 179 (9) | 164 (9) |
| Not available, n | 1387 (74) | 1140 (60) | 971 (52) | 771 (41) | 332 (18) |
| UC extent (hierarchical)a, subsetc | |||||
| 5-year UC diagnosis record, N (%) | 498 (100) | 498 (100) | 498 (100) | 498 (100) | 498 (100) |
| Extensive/pancolitis, n | 298 (60) | 317 (63) | 337 (68) | 357 (78) | 388 (78) |
| Left-sided, n | 112 (22) | 106 (21) | 101 (20) | 89 (18) | 75 (15) |
| Proctitis/Proctosigmoiditis, n | 88 (18) | 75 (15) | 60 (12) | 52 (10) | 35 (7) |
aUC disease extent assigned hierarchically based on diagnosis codes, i.e., precedence given to codes for more extensive disease and carried forward in time
bAmong the total of 1891 patients, six did not have a record of UC diagnosis within the five years prior to initial biologic with post-UC diagnosis status inferred by records of UC treatment alone
cAmong the total of 1885 patients above, 498 had at least one diagnosis record for UC disease extent within each of the 5 years prior to initial biologic