Figure 3.

Tumor suppressive role of HNF4α. Schematic diagram depicting the published mechanisms of the tumor suppressive role of HNF4α in cancer. (A) HNF4α is involved in EMT and stemness regulation through Wnt/β-catenin signalling pathway. (B) HNF4α is regulated by miRNAs, affecting the metabolic enzymes and cellular biology via NOTCH signalling pathway. (C) HNF4α could induce cell cycle arrest and inhibit cell proliferation by competing binding of p21 promotor region to c-Myc protein. (D) HNF4α regulates non-coding RNA expression to control the metastasis gene expression through YAP/Hippo pathway and NF-κB signalling. ADAM17, ADAM metallopeptidase domain 17; Bmp7, bone morphogenetic protein 7; CDKN1A, Cyclin Dependent Kinase Inhibitor 1A; EMT, epithelial-mesenchymal transition; Fus, FUS RNA binding protein; HNF4α, hepatocyte nuclear receptor 4 α; miR, microRNA; Rrm2, ribonucleotide reductase regulatory subunit M2; Set, SET nuclear proto-oncogene.