Table 4.
System | Exotherm | Endotherm | ||
---|---|---|---|---|
Tpeak (°C) | Enthalpy (J/g) | Tpeak (°C) | Enthalpy (J/g) | |
Raw Sim | 129.50 ± 0.11 | 5.94 ± 0.72 | 135.45 ± 0.06 | 63.24 ± 0.55 |
0.1% w/v SD Sim (25% PR) | 126.05 ± 0.13 | 6.7 ± 4.28 | 132.28 ± 0.44 | 36.96 ± 3.08 |
0.1% w/v SD Sim (50% PR) | 123.41 ± 0.6 | 10.35 ± 2.25 | 132.80 ± 0.13 | 42.73 ± 4.53 |
0.5% w/v SD Sim (25% PR) | 120.69 ± 0.47 | 31.24 ± 3.12 | 131.47 ± 1.02 | 29.75 ± 6.48 |
0.5% w/v SD Sim (50% PR) | 120.08 ± 0.52 | 22.04 ± 3.72 | 133.33 ± 0.8 | 40.39 ± 6.97 |
DSC, differential scanning calorimetry; PR, pump rate; SD, spray dried; Sim, simvastatin; Tpeak, transition temperature peak.