Table 5.

Associations between AChE inhibition and depression by gender, adjusted for adrenal and sex hormones.

	Depression score difference per 10% AChE inhibition (β (95% CI))
Adjustments:	No hormones	Cortisol only	DHEA only	Testosterone only	Estradiol only	All hormones excluding estradiol	All hormones
A) Full Sample
Female (n=153)	0.91 (−0.20, 2.03)	0.72 (−0.40, 1.84)	0.95 (−0.18, 2.07)	0.98 (−0.14, 2.09)	−	0.71 (−0.40, 1.81)	-
Male (n=148)	0.70 (−1.25, 2.65)	0.59 (−1.34, 2.53)	0.63 (−1.37, 2.63)	0.59 (−1.34, 2.52)	0.90 (−1.02, 2.81)	0.63 (−1.38, 2.65)	0.91 (−1.07, 2.88)
Difference in β between genders	0.21	0.13	0.32	0.39	-	0.08	-
B) AChE inhibition-matched sample by gender (sensitivity)
Female (n=125)	1.50 (−0.08, 3.07)	1.31 (−0.26, 2.88)	1.55 (−0.04, 3.14)	1.51 (−0.07, 3.09)	-	1.22 (−0.34, 2.77)	-
Male (n=134)	0.77 (−1.49, 3.03)	0.63 (−1.60, 2.87)	0.64 (−1.68, 2.96)	0.63 (−1.60, 2.87)	0.87 (−1.34, 3.09)	0.62 (−1.72, 2.96)	0.74 (−1.55, 3.02)
Difference in β between genders	0.73	0.68	0.91	0.88	-	0.60	-

Adjustments: age, AChE activity at baseline, hemoglobin concentration (baseline and follow-up), z-score for height-for-age, z-score for BMI-for-age, family income, time of saliva sample collection and time of awakening and concentrations of hormones listed