Skip to main content
. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Diabetologia. 2020 Sep 7;63(10):2057–2063. doi: 10.1007/s00125-020-05213-5

Figure 2:

Figure 2:

Glucose-stimulated insulin secretion is one of the most common measurements in the islet biology field. The name of the response implies a straightforward response with glucose as input and insulin as output (a). In reality, a number of alpha cell-derived stimulatory signals (red) offset by paracrine inhibition by delta cells determines the net overall insulin response to glucose stimulation of intact islets.