Scheme 10:
Synthesis of radiotracers via alcohol-promoted CMRF. [b] Pre-clinical evaluation of 7-[18F]Trp and corresponding radioisomers, displaying regional-time activity curves for uptake of 7-[18F]Trp in the skull (blue), pineal gland (red), and dorsal raphe (green) of rats (below). Metabolic stability data republished from Reference 88 with Permission from the ACS.