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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Clin Transl Imaging. 2020 May 26;8(3):167–206. doi: 10.1007/s40336-020-00368-y

Scheme 10:

Scheme 10:

Synthesis of radiotracers via alcohol-promoted CMRF. [b] Pre-clinical evaluation of 7-[18F]Trp and corresponding radioisomers, displaying regional-time activity curves for uptake of 7-[18F]Trp in the skull (blue), pineal gland (red), and dorsal raphe (green) of rats (below). Metabolic stability data republished from Reference 88 with Permission from the ACS.