Table 2.

Association of rs12329760 SNP with severe COVID-19 in Italian population

Genotype	SI cases n = 226		SI controls n = 1848		NIG cases n = 770		NIG controls n = 1915		All cases n = 996		All controls n = 3763		PSI	OR (CI: 95%)	PNIG	OR (CI: 95%)	PAll	OR (CI: 95%)
	n	%	n	%	n	%	n	%	n	%	n	%
CC	164	72.6	1274	68.9	532	69.1	1289	67.3	696	69.9	2563	68.1	–		–		–
CT	57	25.2	497	26.9	220	28.6	554	28.9	277	27.8	1051	27.9	0.47	0.89 (0.64–1.22)	0.68	0.96 (0.79–1.15)	0.71	0.97 (0.83–1.13)
TT	5	2.2	77	4.2	18	2.3	72	3.8	23	2.3	149	4.0	0.14	0.50 (0.20–1.26)	0.06	0.60 (0.35–1.02)	0.01	0.57 (0.36–0.89)
Allele
C	385	85.2	3045	82.4	1284	83.4	3132	81.8	1669	83.8	6177	82.1	–		–		–
T	67	14.8	651	17.6	256	16.6	698	18.2	323	16.2	1349	17.9	0.14	0.81 (0.62–1.07)	0.16	0.89 (0.76–1.04)	0.07	0.89 (0.78–1.01)
Dominant
CC/CT	221	97.8	1771	95.8	752	97.7	1843	96.2	973	97.7	3614	96.0	–		–		–
TT	5	2.2	77	4.2	18	2.3	72	3.8	23	2.3	149	4.0	0.15	0.52 (0.20–1.30)	0.06	0.61 (0.36–1.03)	0.01	0.57 (0.37–0.89)
Recessive
CC	159	70.4	1274	68.9	532	69.1	1289	67.3	691	69.4	2563	68.1	–		–		–
CT/TT	62	27.4	574	31.1	238	30.9	626	32.7	300	30.1	1200	31.9	0.26	0.84 (0.61–1.14)	0.37	0.92 (0.76–1.10)	0.28	0.92 (0.79–1.07)

NIG, Network for Italian Genomes; OR, odds ratio; CI, confidence interval; SI, Southern Italy.

In bold are highlighted the statistically significant results.