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. 2021 Mar 17;21:287. doi: 10.1186/s12885-021-08016-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Number of CTCs during treatment with BRAF/MEK inhibitors. MMbraf1, MMbraf2, MMbraf3, and MMbraf4 were diagnosed with metastatic BRAF^v600E/K melanoma. a Monitoring the number of CTCs during the clinical course in MMbraf1. The graph shows the number of CTCs and the LDH level (upper limit of normal, 230 IU/L). Arrows indicate lung metastases in computed tomography (CT) imaging. b Monitoring the number of CTCs during the clinical course in MMbraf2. Circles indicate a right axillary lymph node (LN) metastasis in CT imaging. c Monitoring the number of CTCs during the clinical course in MMbraf3. Arrowheads indicate a liver metastasis in CT imaging. d Monitoring the number of CTCs during the clinical course in MMbraf4. Arrows indicate a right inguinal LN metastasis in CT imaging