Table 1.
BRAF status of CTCs detected in MMbraf5 during treatment with dabrafenib and trametinib
| BRAF mutation status of CTC | Day − 60 | Day 8 | Day 15 | Day 36 | Day 57 | Day 92 | Day 120 | Day 148 | Treatment suspended |
|---|---|---|---|---|---|---|---|---|---|
| Wild type | 34 | 9 | 14 | 15 | 14 | 6 | 3 | 8 | 17 |
| V600E | 9 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 6 |
| V600R | 0 | 1 | 5 | 2 | 1 | 0 | 0 | 0 | 0 |
| V600M | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| V600A | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| K601E | 4 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 0 |
| K601R | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| A598V | 0 | 2 | 0 | 0 | 1 | 0 | 1 | 3 | 0 |
| The number of isolated CTC | 48 | 17 | 21 | 20 | 18 | 7 | 4 | 11 | 23 |
Day, day before or after treatment started
We did not analyze BRAF genotyp of all isolated CTC at each time point