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. 2021 Mar 16;21:284. doi: 10.1186/s12885-021-07997-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — MiR-503-5p was a direct target of circ_0003266. a. Circular RNA Interactome was used to predict the binding site between circ_0003266 and miR-503-5p. b. Dual-luciferase reporter gene assay was used to confirm the relationship between circ_0003266 and miR-503-5p. c. qRT-PCR was used to detect the expression of miR-503-5p in SW480 and HCT-116 cells transfected with NC, circ_0003266 overexpression plasmids, si-NC, or si-circ_0003266. d. qRT-PCR was used to detect the expression of miR-503-5p in human CRC tissues and adjacent tissues. e. Pearson correlation analysis showed the negative relationship between circ_0003266 and miR-503-5p in CRC tissues. ***P < 0.001