Table 3.
Correlation between COL6A6 expression and gene markers in GEPIA2.
| Immune celltypes | Gene markers | LUAD | |||
|---|---|---|---|---|---|
| Tumor | Normal | ||||
| R | P | R | P | ||
| B cell | CD19 CD79A |
0.33 0.27 |
1.4e−13 1.5e−09 |
0.053 0.15 |
0.69 0.26 |
| T cell (general) | CD2 CD3E |
0.41 0.43 |
1e−20 1e−23 |
0.14 0.29 |
0.3 0.027 |
| CD8+ T cell | CD8ACD8B | 0.34 0.28 |
1.9e−14 5.5e−10 |
0.21 0.055 |
0.11 0.68 |
| CD4+ T cell | CD4 | 0.57 | 5.4e−43 | 0.37 | 0.0035 |
| Natural killer cell | KIR2DL1 KIR2DL3 KIR2DL4 KIR3DL1 KIR3DL2 KIR3DL3 KIR2DS4 |
0.21 0.23 −0.025 0.25 0.18 −0.083 0.15 |
2.7e−06 5.8e−07 0.59 3.9e−08 9.6e−05 0.07 0.0012 |
0.25 0.36 0.15 0.34 0.31 0.04 0.25 |
0.054 0.0057 0.27 0.0078 0.015 0.76 0.054 |
| Neutrophils | CD66b CD11b CCR7 |
0.37 0.42 0.52 |
1.9e−174 4e−22 5.7e−35 |
0.07 0.086 0.14 |
0.6 0.52 0.29 |
| Th1 | T-bet STAT4 TNF-α |
0.4 0.38 0.25 |
2.7e−20 5.3e−18 2.3e−08 |
0.45 0.29 0.17 |
0.00032 0.028 0.21 |
| Th2 | GATA3 STAT6 STAT5A IL13 |
0.31 0.32 0.49 0.27 |
5.2e−12 1e−12 3.1e−30 9.3e−10 |
0.45 0.6 0.34 0.25 |
0.00034 5.8e−07 0.0092 0.058 |
| Tfh | BCL6 | 0.26 | 9.4e−09 | 0.51 | 4.5e−05 |
| Th17 | STAT3 IL17A |
0.29 0.13 |
1.4e−10 0.0045 |
0.54 0.12 |
8.5e−06 0.37 |
| Mast cells | TPSB2 TPSAB1 CPA3 MS4A2 HDC |
0.45 0.49 0.55 0.6 0.57 |
3.1e−25 4.3e−31 9.1e−40 5.3e−49 1.2e−42 |
0.33 0.42 0.45 0.5 0.43 |
0.011 0.001 4e−04 4.8e−05 0.00061 |
| Eosinophils | IL5 CD125 |
0.17 0.43 |
2e−04 7.2e−23 |
-0.038 0.055 |
0.77 0.68 |
| Monocytes | CD86 CX3CR1 CD14 |
0.38 0.45 0.27 |
6e−18 8.8e−26 1.9e−09 |
-0.13 0.43 0.12 |
0.31 6e−04 0.36 |
| Checkpoints | PDCD1 CD274 CTLA4 LAG3 TIGIT |
0.25 0.27 0.32 0.15 0.37 |
1.8e−08 1.2e−09 3.7e−13 0.0014 1.5e−17 |
0.17 0.24 0.37 0.12 0.3 |
0.2 7.1e−06 0.0038 0.38 0.022 |
GEPIA2, Gene Expression Profiling Interactive Analysis 2; LUAD, lung adenocarcinoma; Th1, T helper 1 cells; Th2, T helper 2 cells; Tfh, follicular helper T cells; Th17, T helper cell 17.