Table 1.

Prognostic significance of genetic mutations and copy number variations by univariate and multivariate cox proportional hazard model.

Variable	Population (%)	Univariate		Multivariate
		HR (95% CI)	P value	HR (95% CI)	P value
WHO Grade	–	–	<0.001	–	0.09
Surgical resection	–	–	0.04	–	0.02
Radiotherapy	85(76%)	0.36 (0.21–0.63)	<0.001	0.24 (0.13–0.46)	<0.001
H3 K27M	32(29%)	1.73 (1.06–2.83)	0.03	1.49 (0.67–3.28)	0.33
TP53	35(31%)	1.52 (0.93–2.5)	0.09	1.18 (0.63–2.22)	0.6
TERT	27(24%)	2.17 (1.28–3.67)	0.003	3 (1.37–6.61)	0.01
EGFR	19(17%)	1.75 (0.98–3.13)	0.05	0.87 (0.4–1.89)	0.73
PIK3CA	16(14%)	2.04 (1.08–3.84)	0.02	3.01 (1.38–6.54)	0.01
PIK3R1	7(6%)	2.23 (0.95–5.23)	0.06	1.23 (0.46–3.32)	0.68
APC	7(6%)	0.30 (0.07–1.25)	0.08	0.23 (0.05–1.05)	0.06
MCL1 CNV	35(31%)	1.81 (1.11–2.95)	0.02	2.78 (1.53–5.08)	<0.001
EGFR CNV	19(17%)	3.78 (2.09–6.85)	<0.001	2.3 (0.97–5.48)	0.06
CDK6 CNV	7(6%)	2.69 (1.15–6.3)	0.02	2.01 (0.63–6.43)	0.24