. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Exp Mech. 2020 Aug 11;61(1):131–146. doi: 10.1007/s11340-020-00643-z

Table-2:

Model parameters for LV mechanics

Description	Parameter	Pig 1	Pig 2	Pig 3	Pig 4
Material parameter, kPa	C	0.077	0.06	0.0094	0.0054
Material parameter	b_ff	29.0	29.0	29.0	29.0
Material parameter	b_xx	26.6	26.6	26.6	26.6
Material parameter	b_fs	13.3	13.3	13.3	13.3
Isometric tension under maximal activation, kPa	T_max	45	61.3	51.1	57.2
Peak intracellular calcium concentration, μM	Ca₀	4.35	4.35	4.35	4.35
Maximum peak intracellular calcium concentration, μM	(Ca₀)_max	4.35	4.35	4.35	4.35
Governs shape of peak isometric tension-sarcomere length relation, μm⁻¹	B	4.75	4.75	4.75	4.75
Sarcomere length at which no active tension develops, μm	l₀	1.58	1.58	1.58	1.58
Time to peak tension, ms	t₀	320	270	300	270
Slope of linear relaxation duration-sarcomere length relation, ms μm⁻¹	m	240	265	240	220
Time-intercept of linear relaxation duration-sarcomere length relation, ms	b	−220	−255	−220	−220
Relaxed sarcomere length, μn	I_r	1.85	1.85	1.85	1.85
Windkessel Parameter		Baseline model
Aortic valve compliance, ml Pa	c_a	0.0075	0.0025	0.0073	0.0035
Peripheral resistance, Pa ms ml⁻¹	R_p	170000	110500	48000	70000
Aortic valve resistance, Pa ms ml⁻¹	R_a	9000	0.000005	0.00005	1000
Windkessel parameter		Acute overload model
Aortic valve compliance, ml Pa	c_a	0.0055	0.0014	0.004	0.0028
Peripheral resistance, Pa ms ml⁻¹	R_p	12000000	37570000	18000000	23760000
Aortic valve resistance, Pa ms ml⁻¹	R_a	20000	50000	40000	17000