Table-2:

Model parameters for LV mechanics

Description	Parameter	Pig 1	Pig 2	Pig 3	Pig 4
Material parameter, kPa	C	0.077	0.06	0.0094	0.0054
Material parameter	bff	29.0	29.0	29.0	29.0
Material parameter	bxx	26.6	26.6	26.6	26.6
Material parameter	bfs	13.3	13.3	13.3	13.3
Isometric tension under maximal activation, kPa	Tmax	45	61.3	51.1	57.2
Peak intracellular calcium concentration, μM	Ca0	4.35	4.35	4.35	4.35
Maximum peak intracellular calcium concentration, μM	(Ca0)max	4.35	4.35	4.35	4.35
Governs shape of peak isometric tension-sarcomere length relation, μm−1	B	4.75	4.75	4.75	4.75
Sarcomere length at which no active tension develops, μm	l0	1.58	1.58	1.58	1.58
Time to peak tension, ms	t0	320	270	300	270
Slope of linear relaxation duration-sarcomere length relation, ms μm−1	m	240	265	240	220
Time-intercept of linear relaxation duration-sarcomere length relation, ms	b	−220	−255	−220	−220
Relaxed sarcomere length, μn	Ir	1.85	1.85	1.85	1.85
Windkessel Parameter		Baseline model
Aortic valve compliance, ml Pa	ca	0.0075	0.0025	0.0073	0.0035
Peripheral resistance, Pa ms ml−1	Rp	170000	110500	48000	70000
Aortic valve resistance, Pa ms ml−1	Ra	9000	0.000005	0.00005	1000
Windkessel parameter		Acute overload model
Aortic valve compliance, ml Pa	ca	0.0055	0.0014	0.004	0.0028
Peripheral resistance, Pa ms ml−1	Rp	12000000	37570000	18000000	23760000
Aortic valve resistance, Pa ms ml−1	Ra	20000	50000	40000	17000