FIGURE 2.

The contribution of neutrophils to the inflammatory response to injury. Following traumatic injury, elevations in circulating neutrophils are initiated by the release of chemoattractants and demargination from the intravascular pool. Additionally, neutrophils become activated, resulting in the release of proteases, NETs, ROS and cytokines. Whilst these processes can result in the clearance of tissue debris and pathogens, they can also lead to further endothelial activation, inflammation and tissue damage