Table 4.
Adverse events in the group given chemotherapy plus PRM1201 and chemotherapy plus Placebo (n [%]).
| Adverse Event | Chemo+PRM1201 | Chemo+Placebo | P value | ||
|---|---|---|---|---|---|
| Grade 3 | Grade 4 | Grade 3 | Grade 4 | ||
| Neutropenia | 36 (19.6) | 11 (6.0) | 45 (24.5) | 16 (8.6) | 0.292 |
| Anemia | 3 (1.6) | 2 (1.1) | 4 (2.2) | 2 (1.1) | 0.935 |
| Thrombocytopenia | 4 (2.2) | 2 (1.1) | 6 (3.2) | 2 (1.1) | 0.609 |
| Nausea† | 6 (3.2) | NA | 10 (5.5) | NA | 0.317 |
| Diarrhea | 16 (8.7) | 2 (1.1) | 22 (11.8) | 3 (1.6) | 0.545 |
| Vomiting | 8 (4.3) | 2 (1.1) | 14 (7.5) | 1 (0.1) | 0.371 |
| Paresthesia† | 22 (12.0) | NA | 20 (10.8) | NA | 0.715 |
| Hand-foot Syndrome | 4 (2.2) | 1 (0.1) | 4 (2.2) | 2 (1.1) | 0.850 |
†There are only three grades of nausea and paresthesia in the Common Terminology Criteria of the National Cancer Institute (NCI-CTC, version 4.0). NA demotes not applicable.