Figure 3.

MRI analysis of the progression of NM-induced lung injury and the effects of anti-TNF-α antibody. (A) FSE MRI images were acquired from the same anatomical position 1, 3, 7, 14 and 28 d following CTL (n = 6) or NM (n = 6) exposure. Lung volume is indicated by the area within the blue outline and lung injury by the area within the red outlines. Representative images are shown. (B) Total lung volume (mm3) and volume of lung injury (mm3) were quantified 1, 3, 7, 14, 21 and 28 d following exposure of rats to NM (n = 6) and NM + anti-TNF-α antibody (n = 8). Data are presented as percentage of injured lung area detected in MRI images relative to total lung volume. Data are mean ± SE.